Is MAVI compatible with Peter Attia's Medicine 3.0?

Yes — they are non-overlapping and additive. Medicine 3.0 specifies what the body needs (diagnostics, exercise, sleep, lipid management). MAVI specifies the residence that produces or denies those inputs across the 23-hour exposure window medicine cannot reach.

A complete prevention practice has both. A Medicine 3.0 patient in a high-PM2.5, low-melanopic, high-EMF home is undoing measurable percentages of the protocol every day. The architecture half closes the loop.

How does MAVI relate to the four horsemen?

Each MAVI domain maps to one or more horsemen. Air, water, materials, and EMF map to cancer-and-inflammation. Light, temperature, and sound map to cardiovascular and metabolic. Microbiology maps to neurodegenerative via the gut-brain axis. The architecture is the upstream environmental input to all four.

MAVI vs Peter Attia — the body and the room

The most coherent framework for prevention published in the last decade is Peter Attia’s Outlive. Medicine 3.0 treats prevention as the central act of medicine, with the four horsemen — cardiovascular disease, metabolic disease, neurodegenerative disease, and cancer — as the targets the slope of the last forty years bends against.

What Medicine 3.0 does not address is the architectural environment in which the patient is doing all of this. MAVI is that layer.

Discipline	Medicine 3.0	MAVI
Subject of optimisation	The body. Diagnostics, prevention, the four horsemen (cardiovascular, metabolic, neurodegenerative, cancer), Zone 2 cardio, lipid management, sleep architecture.	The architecture around the body. Air, water, light, sound, temperature, materials, microbiology, EMF, mind, habits.
Methodology	Medicine 3.0 — proactive, individualised, prevention-first medicine. Targets the slope of the last forty years through earlier intervention.	MAVI 129™ — peer-reviewed framework scoring residences against 129 measurable factors. Targets the 23-hour-a-day exposure environment medicine cannot reach.
Time horizon	Decades of biomarker tracking and protocol iteration. Slow medicine.	Slow architecture. Specifications outlive supplements. The room is what compounds.
Where the leverage is	Inside the body. Glucose, lipids, VO₂ max, sleep stages, body composition, mental health.	Outside the body. The room produces the air the lungs draw, the light the retina samples, the temperature the metabolism regulates against.
What it cannot do	Cannot redesign the residence the patient lives in. Medicine 3.0 stops at the building envelope.	Cannot replace the diagnostic, the supplements, the training dose. The architecture half is non-substitutive.
How they fit together	Specifies what the body needs.	Specifies the room that delivers, or denies, those inputs continuously.

The body half and the architecture half.

Medicine 3.0 specifies what the body needs. MAVI specifies the room that produces, or fails to produce, those inputs. Either alone is partial; together they describe the full prevention stack.

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